The complete loss or absence of hope.
Lose or be without hope.
Middle English: the noun via Anglo-Norman French from Old French desespeir; the verb from Old French desperer, from Latin desperare, from de- ‘down from’ + sperare ‘to hope’.
Do not despair. In spite of ODO reaching the nadir of repeating words [again, again, again], we search the vast list of words for a gem, a diamond in the rough, a worthy substitute, a fabulous find.